alveolar cells – Communicable Diseases Research

A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate response

Article

Published on 2022-12-212022-11-15
Journal: Journal of theoretical biology
[Category] COVID19(2023년), SARS, 변종, 치료제,

SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways

인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다

Article

Published on 2022-07-012022-09-12
Journal: Journal of cellular physiology
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response Complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation
[DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article

ACE2 and Innate Immunity in the Regulation of SARS-CoV-2-Induced Acute Lung Injury: A Review

Review

Published on 2021-10-252022-10-29
Journal: International Journal of Molecular Sciences
[Category] COVID-19, MERS, SARS,

7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19

7-케토콜레스테롤: 바이러스 감염에 미치는 영향 및 COVID-19에 대한 가설적 기여

Review

Published on 2021-09-012022-09-11
Journal: The Journal of steroid biochemistry and molecular
[Category] MERS, 바이오마커, 치료제,

[키워드] 7-Ketocholesterol activate activities activity acute respiratory distress acute respiratory distress syndrome adjuvant adjuvant therapies adjuvant therapy affected Age-related macular degeneration alveolar cells Alzheimer's disease Anti-viral antiviral activity Apoptosis appear assumed auto-oxidation autophagy Biomarker cancers cardiovascular diseases cell death cholesterol chronic inflammatory bowel diseases concentrations contribute contributing to COVID-19 COVID-19 patients Deleterious density disease Diseases Effect food hypothetical Inflammatory bowel disease inflammatory bowel diseases involved macular degeneration outcome Oxidation oxidized oxysterol Oxysterols pathophysiology pro-inflammatory produced promote provided recent respiratory distress Respiratory distress syndrome resulting SARS-CoV-2 serum shown side chain significantly suggested syndrome toxic effect toxic effects Viral Viral diseases viral diseases. viral infection
[DOI] 10.1016/j.jsbmb.2021.105939 PMC 바로가기 [Article Type] Review

Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients

Article

Published on 2021-08-122022-10-28
Journal: Biomedicines
[Category] COVID-19,

[키워드] Activation Alternative pathway alveolar cells analysis antibody Autopsy C1q capillary caused circulating classical classical pathway complement Complement activation component COVID-19 COVID-19 patient COVID-19 patients Deceased deposition detectable determine died distribution IgG immunofluorescence Increased Inflammation information kidney kidneys liver Local lung Lungs MASP-2 mechanism Mild multi-organ deposition organ pathway Patient patients with COVID-19 performed reported Respiratory failure SARS-CoV-2 specimen Spike protein staining Support the disease tissue tissue damage vessel were stained
[DOI] 10.3390/biomedicines9081003 PMC 바로가기 [Article Type] Article

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Public Health

Published on 2021-07-282022-10-31
Journal: Frontiers in Public Health
[Category] COVID-19, MERS, SARS,

[키워드] accelerate ACE2 ACE2 receptor Affect aggravate airways alveolar cells article ASL blood glucose carbohydrates Cell cell damage cell death cells Combination Complication computational modeling Concentration condition COVID-19 Critical care Cytokine storm database diagnostic disease disease severity dysregulated dysregulation Effect elevated Elevation evade Evidence explain facilitate feasibility Glucose glycemia glycemic control Glycolysis glycosylation hyper-inflammation hyperglycemia Hypothesis immune defense inactivation induce Infection infection process infections Inflammation information innate immune system involved Ketogenic diet knowledge Level lung Lungs machine learning model MOST multi-organ failure multiple mechanism pandemic potential treatments progression proportion provide pulmonary inflammatory response Quantitative reached replicate Replication Research risk role SARS-CoV-2 Severe case severe COVID-19 severity subsequent Symptoms tested the cytokine storm the disease the patient the SARS-CoV-2 Thrombotic events treatment strategy View viral infection Viral load virus weakened
[DOI] 10.3389/fpubh.2021.695139 PMC 바로가기 [Article Type] Public Health

Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection

Review

Published on 2021-07-262022-10-29
Journal: International Journal of Molecular Sciences
[Category] COVID-19,

[키워드] “cytokine storm” ACE2 acid Activation acute respiratory syndrome addition alpha-lipoic acid alveolar cells Analysis anti-inflammatory effect antioxidant appear ARDS binding blood vessels cardiovascular cardiovascular comorbidity cardiovascular disease caused cellular entry Coagulopathy complex Complication contribute coronavirus Coronavirus disease 2019 COVID-19 COVID-19 complications COVID-19 infection Critical critical condition death distress distribution dysfunction endothelial Endothelial cell Endothelial dysfunction endothelial function Endothelium Evolution expressed global pandemic high risk homeostasis human Angiotensin-converting enzyme immune system IMPROVE independent induce infected with SARS-CoV-2 Infection Inflammation information insight interfere lung Mechanics mechanism microthrombi mitochondrial Mitochondrial function multiorgan failure Myocardial infarction nitric oxide oxidative stress pathology pathway Patient Perspective predominant Prognosis proinflammatory protease Protein reactive oxygen specy receptor redox status reduced reported Respiratory disease SARS-CoV-2 SARS-COV-2 infection serine 2 severe COVID-19 signaling pathways small intestine Spread stroke the S protein the SARS-CoV-2 therapeutic therapy thrombosis tissue TMPRSS2 transmembrane underlying diseases upregulation viral infection viral surface virus Wuhan, China
[DOI] 10.3390/ijms22157979 PMC 바로가기 [Article Type] Review

Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19

GS-441524의 세포 흡수 및 세포 내 인산화 : Covid-19에 대한 효과에 대한 영향

Review

Published on 2021-07-142022-09-10
Journal: Viruses
[Category] SARS, 치료제,

[키워드] adenosine adenosine analogs adenosine kinase adenosine levels adenosine transporters alveolar cell alveolar cells alveoli anticancer Antiviral approval cellular cellular uptake clinical effectiveness COVID-19 Critical decrease decreased expression disease effective Effectiveness epithelial cell epithelial cells expressed expression Extracellular GS-441524 healthy hypoxia illnesses Increases increases in Inflammation Intracellular knowledge lead limit Lungs monophosphate nucleoside occur outcome parent nucleoside pharmacokinetic Phosphorylation pneumocyte Pneumocytes protein expression reduced Remdesivir SARS-CoV-2 severe inflammation therapeutic tissue tissues Treatment treatment of COVID-19 triphosphate uptake
[DOI] 10.3390/v13071369 PMC 바로가기 [Article Type] Review

A macrophage attack culminating in microthromboses characterizes COVID 19 pneumonia

미세혈전증에서 정점을 이루는 대식세포 공격은 COVID 19 폐렴을 특징짓습니다

Original Article

Published on 2021-07-072022-09-10
Journal: Immunity, Inflammation and Disease
[Category] SARS, 치료기술,

[키워드] acute phase alveolar cells Bacterial bacterial pneumonia Blood level blood levels blood tissues bloodstream Brain caused characteristic circulation clotting Coagulation complexes COVID COVID 19 COVID‐19 COVID‐19 patient disorders Disseminated intravascular coagulation Effect elevated Evidence evidence of explain ferritin ferritin level FIBRIN fibrin clot fibrinogen FIVE Frequency human animals ICU immune immune activation immune response infections infiltrating infiltration Innate immunity input intravascular coagulation kidney Liver transplantation lung infiltrates Lungs Macrophage Macrophage infiltration macrophages monomer neutrophilic organ oropharynx pandemic panoply Patient patients phagocytic Pneumonia Protein Proteins prothrombotic referred to reflect respiratory respiratory virus Result SARS‐CoV‐2 tandem thought thrombocytopenia THROMBOPLASTIN tissue Tissue Factor vasculature Viral Viral pneumonia viral retroviral virus Whole blood
[DOI] 10.1002/iid3.482 PMC 바로가기 [Article Type] Original Article

The Recombination Potential between SARS-CoV-2 and MERS-CoV from Cross-Species Spill-over Infections

종간 전파 감염으로 인한 SARS-CoV-2와 MERS-CoV의 재조합 가능성

Article

Published on 2021-06-012022-09-11
Journal: Journal of Epidemiology and Global Health
[Category] SARS, 유전자 메커니즘, 조류인플루엔자, 치료기술,

[키워드] acute respiratory syndrome coronavirus alveolar cell alveolar cells angiotensin angiotensin converting enzyme both virus both viruses Cell Cluster Co-infection coronavirus 2 COVID-19 cross-over dipeptidyl peptidase Dipeptidyl peptidase-4 dromedary camels feasible generate Genes high recombination Host humans identify infect mechanisms MERS MERS-CoV Middle-Eastern Respiratory Syndrome Coronavirus ORF1a ORF1b organelle outbreak Pneumonia Potential recognizing Recombination recombination. Replication respiratory respiratory illness respiratory illnesses RNA SARS-CoV-2 sequence sequence homology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein Spike proteins Transcription Transcription Regulatory Sequences TRS TRSs virus virus whole genome
[DOI] 10.2991/jegh.k.201105.001 PMC 바로가기 [Article Type] Article